Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

@article{Kawakami1988Interleukin4P,
  title={Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma},
  author={Yutaka Kawakami and Steven A Rosenberg and Michael T Lotze},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={168},
  pages={2183 - 2191}
}
Addition of IL-4 (1,000 U/ml) to either high or low concentrations of IL-2 augmented tumor-infiltrating lymphocytes (TIL) growth from human melanoma. Weekly restimulation with irradiated tumor cells in conjunction with IL-4 allowed enhanced growth of TIL. With low-dose IL-2 (10 U/ml) and IL-4, expanded TIL had little cytolytic activity against Daudi or allogeneic tumors. Further, IL-4 augmented the total lytic activity against autologous tumors in most cases. With high-dose IL-2 (1,000 U/ml… CONTINUE READING
47 Citations
4 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-4 of 4 references

Therapy ofpatients with advanced cancer using tumor infiltrating lymphocytes

  • C . N . Robertson, C. A . Seipp, P Simon, C . G. Simpson, S . A. Rosenberg
  • 1988

Identificatio n of specific cytolytic immune responses against autologous tumor in humans bearing malig

  • Engl. J Med
  • 1987

Similar Papers

Loading similar papers…