Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts.

@article{Yamada2007Interleukin4IO,
  title={Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts.},
  author={Atsushi Yamada and Masamichi Takami and Tadaharu Kawawa and Rika Yasuhara and Baohong Zhao and Ayako Mochizuki and Yoichi Miyamoto and Tomoo Eto and Hisataka Yasuda and Yuko Nakamichi and Nacksung Kim and Takenobu Katagiri and Tatsuo Suda and Ryutaro Kamijo},
  journal={Immunology},
  year={2007},
  volume={120 4},
  pages={573-9}
}
Interleukin (IL)-4 and IL-13 are closely related cytokines known to inhibit osteoclast formation by targeting osteoblasts to produce an inhibitor, osteoprotegerin (OPG), as well as by directly targeting osteoclast precursors. However, whether their inhibitory actions are the same remains unclear. The inhibitory effect of IL-4 was stronger than that of IL-13… CONTINUE READING