Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter

@article{Liddiard2006Interleukin4IO,
  title={Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter},
  author={Kate Liddiard and John S. Welch and Jean Lozach and Sven Heinz and Christopher K. Glass and David Greaves},
  journal={BMC Molecular Biology},
  year={2006},
  volume={7},
  pages={45 - 45}
}
Macrophages (Mθ) play a central role in the innate immune response and in the pathology of chronic inflammatory diseases. Macrophages treated with Th2-type cytokines such as Interleukin-4 (IL-4) and Interleukin-13 (IL-13) exhibit an altered phenotype and such alternatively activated macrophages are important in the pathology of diseases characterised by allergic inflammation including asthma and atopic dermatitis. The CC chemokine Thymus and Activation-Regulated Chemokine (TARC/CCL17) and its… CONTINUE READING

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