Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses.

@article{Cenci1999Interleukin4CS,
  title={Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses.},
  author={Elio Cenci and A ntonella Mencacci and Giuseppe Del Sero and Angela Bacci and Claudia Montagnoli and Cristiana Fe' d'Ostiani and Paolo Mosci and Malte Bachmann and Francesco Bistoni and Manfred Kopf and Luigina Romani},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={180 6},
  pages={1957-68}
}
Aspergillus fumigatus, an opportunistic fungal pathogen, causes multiple allergic and nonallergic airway diseases. Invasive pulmonary aspergillosis (IPA) is a nonallergic, life-threatening disease of immunocompromised patients. In a murine model of IPA, interleukin (IL)-4-deficient (IL-4-/-) BALB/c mice were used to examine the role of IL-4 in lung pathology and immune responses. IL-4-/- mice were more resistant than wild-type mice to infection caused by multiple intranasal injections of viable… CONTINUE READING

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