Interleukin-4 but not interleukin-10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes.

@article{Dchanet1994Interleukin4BN,
  title={Interleukin-4 but not interleukin-10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes.},
  author={Julie D{\'e}chanet and Jean Luc Taupin and Pascale Chomarat and M C Rissoan and Jean François Moreau and Jacques Banchereau and Pierre Miossec},
  journal={European journal of immunology},
  year={1994},
  volume={24 12},
  pages={3222-8}
}
The expression of the proinflammatory cytokine leukemia inhibitory factor (LIF) has been reported in the cartilage and synovium of rheumatoid arthritis (RA) patients. Here, we show that high levels of LIF were constitutively produced by cultures of synovium pieces. Low levels of LIF were produced spontaneously by isolated synoviocytes, but interleukin (IL)-1 beta caused a fourfold enhancement of this secretion. The anti-inflammatory cytokine IL-4 reduced the production of LIF by synovium pieces… CONTINUE READING