Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion.

@article{Znd1996Interleukin4AI,
  title={Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion.},
  author={Gregor Z{\"u}nd and James L. Madara and Andrea L Dzus and Christopher S. Awtrey and Sean P Colgan},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 13},
  pages={7460-4}
}
Intestinal epithelia are in intimate contact with subepithelial and intraepithelial lymphocytes. When stimulated, mucosal lymphocytes generate cytokines that act locally and influence functional aspects of many cell types. We have previously defined functional epithelial receptors for interferon-gamma, interleukin (IL)-4, and a recently described IL-4-like cytokine IL-13. In this study, we examine the ion transport properties of T84 cells, a crypt-like epithelial cell line, following exposure… CONTINUE READING