Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study.

@article{Pousset1999Interleukin4AI,
  title={Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study.},
  author={Françoise Pousset and Sandrine Cremona and Robert Dantzer and Keith W. Kelley and Patricia Parnet},
  journal={Glia},
  year={1999},
  volume={26 1},
  pages={12-21}
}
The pro-inflammatory cytokine interleukin-1beta (IL-1beta) is strongly expressed during brain injury and is able to induce severe cellular brain damage via the production of soluble factors. Different processes regulate IL-1 biological activities, like the production of anti-inflammatory cytokines such as interleukin-4 (IL-4) and interleukin-10 (IL-10). In this report, we describe the sequential effects of IL-4 and IL-10 on the production of interleukin-6 (IL-6) induced by IL-1beta in mouse… CONTINUE READING

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