Interleukin 4: signalling mechanisms and control of T cell differentiation.

  title={Interleukin 4: signalling mechanisms and control of T cell differentiation.},
  author={W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  journal={Ciba Foundation symposium},
  pages={208-16; discussion 216-9}
Interleukin 4 (IL-4) is a pleiotropic type I cytokine that controls both growth and differentiation among haemopoietic and non-haemopoietic cells. Its receptor is a heterodimer. One chain, the IL-4R alpha chain, binds IL-4 with high affinity and determines the nature of the biochemical signals that are induced. The second chain, gamma c, is required for the induction of such signals. IL-4-mediated growth depends upon activation events that involve phosphorylation of Y497 of IL-4R alpha, leading… CONTINUE READING


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