Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.

@article{Wirtz2011Interleukin35MM,
  title={Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.},
  author={Stefan Wirtz and Ulrike Billmeier and Tamuna Mchedlidze and Richard S Blumberg and Markus F Neurath},
  journal={Gastroenterology},
  year={2011},
  volume={141 5},
  pages={1875-86}
}
BACKGROUND & AIMS The soluble hematopoietin receptor Epstein-Barr virus-induced protein (EBI)-3 is an immune regulator that has been associated with the pathogenesis of inflammatory bowel disease. However, the concept that EBI3 is part of an interleukin (IL)-27 heterodimer that mediates chronic inflammatory and autoimmune diseases has been challenged by the description of IL-35, a bioactive cytokine comprising EBI3 and IL-12 p35. We investigated the roles of IL-27 and IL-35 in chronic… CONTINUE READING