Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.

  title={Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.},
  author={Stephanie Zwicker and Gisele Lago Martinez and Madeleen Bosma and Marco Gerling and Reuben Clark and Mirjam Majster and Jan S{\"o}derman and Sven Almer and Elisabeth A Bostr{\"o}m},
  journal={Clinical science},
  volume={129 3},
IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor). However, expression and involvement of IL-34 in… CONTINUE READING
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