Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

@article{Mun2010Interleukin33SF,
  title={Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes},
  author={Se Hwan Mun and Na Young Ko and Hyuk Soon Kim and Jie Wan Kim and Do Kyun Kim and A-Ram Kim and Seung Hyun Lee and Yong-Gil Kim and Chang Keun Lee and Seoung Hoon Lee and Bo Kyung Kim and Michael A. Beaven and Young Mi Kim and Wahn Soo Choi},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={67},
  pages={3883-3892}
}
Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14+ monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)+ multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33… CONTINUE READING
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