Interleukin 33 is a guardian of barriers and a local alarmin

  title={Interleukin 33 is a guardian of barriers and a local alarmin},
  author={Nikolas T Martin and Michael Uwe Martin},
  journal={Nature Immunology},
Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing number of target cells and a plethora of biological functions. Although it has commonalities with other IL-1 cytokines, IL-33 exhibits some unique features. Here we review the biology of IL-33 and its receptor and develop a working model that describes two 'lives' for IL-33—one intracellular and one extracellular. Under healthy conditions, constitutively produced, intracellular IL-33 participates in maintaining… CONTINUE READING
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