Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

@article{AlvesFilho2010Interleukin33AS,
  title={Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection},
  author={Jose C Alves-Filho and Fabiane S{\^o}nego and Fabr{\'i}cio Oliveira Souto and Andressa Freitas and Waldiceu A Verri and Maria Auxiliadora-Martins and An{\'i}bal Basile-Filho and Andrew N. J. McKenzie and D -M. Xu and Fernando Q Cunha and Foo Yew Eddy Liew},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={708-712}
}
Sepsis is a systemic inflammatory condition following bacterial infection with a high mortality rate and limited therapeutic options. Here we show that interleukin-33 (IL-33) reduces mortality in mice with experimental sepsis from cecal ligation and puncture (CLP). IL-33–treated mice developed increased neutrophil influx into the peritoneal cavity and more efficient bacterial clearance than untreated mice. IL-33 reduced the systemic but not the local proinflammatory response, and it did not… CONTINUE READING