Interleukin-32δ interacts with IL-32β and inhibits IL-32β-mediated IL-10 production.

@article{Kang2013Interleukin32IW,
  title={Interleukin-32δ interacts with IL-32β and inhibits IL-32β-mediated IL-10 production.},
  author={J Kang and Yun Sun Park and Dong Hun Lee and Man Sub Kim and Yesol Bak and Su Ho Park and Sun Young Ham and Young Yang and Jin Tae Hong and Do-Young Yoon},
  journal={FEBS letters},
  year={2013}
}
There is growing evidence for multifunctional properties of IL-32. We previously demonstrated that IL-32β upregulates IL-10 production through the association with PKCδ. In this study, we examined the effects of other IL-32 isoforms on IL-10 production. We found that IL-32δ decreased IL-10 production and investigated the inhibitory mechanism of IL-32δ. We showed that IL-32δ suppressed IL-32β binding to PKCδ by interacting with IL-32β. The inhibitory effect of IL-32δ on IL-32β association with… CONTINUE READING

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