Interleukin 32, inflammation and cancer
@article{Hong2017Interleukin3I, title={Interleukin 32, inflammation and cancer}, author={Jin Tae Hong and Dong Ju Son and Chong Kil Lee and Do-Young Yoon and Dong Hun Lee and Mi hee Park}, journal={Pharmacology \& Therapeutics}, year={2017}, volume={174}, pages={127–137} }
89 Citations
Interleukin 22 in Liver Injury, Inflammation and Cancer
- Medicine, BiologyInternational journal of biological sciences
- 2020
Treatment with IL-22 activates hepatic signal transducer and activator of transcription 3 (STAT3), ameliorates hepatic oxidative stress and alcoholic fatty liver, effectively alleviate the liver damage caused by alcohol and toxicant.
Role of interleukin ‐ 32 in cancer biology ( Review )
- Biology
- 2018
This is a review of the current literature on the regulation and function of IL‐ 32 in cancer progression, focusing on the molecular pathways linking IL‐32 and tumour development.
Interleukin-32: its role in asthma and potential as a therapeutic agent
- Biology, MedicineRespiratory Research
- 2018
Recent advances in the pathophysiology of asthma are summarized and the possibilities of using IL-32 as an airway inflammation biomarker and an asthma therapeutic agent are evaluated.
Dendritic Cell–Derived IL-32α: A Novel Inhibitory Cytokine of NK Cell Function
- BiologyThe Journal of Immunology
- 2017
It is found that IL-15 is a potent inducer of IL-32α in DCs and the findings suggest a feedback inhibition ofIL-15–mediated NK cell activity by IL- 32α.
Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer
- Biology, MedicineCell Communication and Signaling
- 2019
The findings demonstrate a novel role of IL-32θ as an intracellular modulator to suppress macrophage-promoted breast cancer progression by targeting CCL18-dependent signaling.
A Paradoxical Effect of Interleukin-32 Isoforms on Cancer
- BiologyFrontiers in Immunology
- 2022
The paradoxical effect of IL-32 on cancer is attributed to the dominant isoform, cancer type, tumor microenvironment, and genetic background and investigating multiple IL- 32 isoforms could bring us closer to using them in therapy.
Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration
- Biology, MedicineCellular Oncology
- 2019
It is found that TC-induced macrophages induced IL-32 expression in TC cells and that TAM-derived TNFα was the main inducer of IL- 32β expression inTC cells, which may be beneficial for TC cell survival through induction of the pro-survival cytokine IL-8.
Elevated Gene Expression of Interleukin-32 Isoforms Alpha, Beta, Gamma, and Delta in the Peripheral Blood of Chronic Psoriatic Patients
- Biology, MedicineDiseases
- 2018
This is the first study that shows the role of IL-32 and its isoforms in the peripheral blood of psoriatic patients and suggests that a major proinflammatory response ofIL-32 may derive from IL- 32α isoform in psoriasis.
Protein Expression and Genetic Variation of IL32 and Association with Colorectal Cancer in Swedish Patients.
- Biology, MedicineAnticancer research
- 2018
The results suggest that altered IL32 protein concentrations in CRC tissue and genotypic variants of IL32 are related to disseminated CRC.
References
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Identification of the most active interleukin‐32 isoform
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A specific target will be provided to neutralize endogenous IL‐32, which may contribute to basic and clinical immunology and to produce recombinant protein with a high yield.
IL‐32 up‐regulation is associated with inflammatory cytokine production in allergic rhinitis
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- 2011
In nasal mucosa tissue from AR patients, the level of IL‐32 production correlated with inflammation, IL‐1β,IL‐18, and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) and depletion of IL-32 prevents the production of inflammatory cytokines in eosinophils.
Interleukin-32β Propagates Vascular Inflammation and Exacerbates Sepsis in a Mouse Model
- Biology, MedicinePloS one
- 2010
The results reveal an important function of IL-32 in vascular inflammation and sepsis development, demonstrated by significant elevation of leukocyte infiltration and serum levels of TNFα and IL-1β, increased vascular permeability and lung damage, and accelerated animal death.
Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases
- Biology, MedicineArthritis research & therapy
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It is concluded that IL-32 is closely associated with TNF α, and contributes to the exacerbation of TNFα-related inflammatory arthritis and colitis.
Interleukin‐32: A new proinflammatory cytokine involved in hepatitis C virus‐related liver inflammation and fibrosis
- Biology, MedicineHepatology
- 2011
IL‐32 is a novel proinflammatory cytokine involved in HCV‐associated liver inflammation/fibrosis and its expression is regulated by proinflammatory stimuli.
Interleukin-32 Expression in the Pancreas
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- 2009
Pancreatic duct cells are the local source of IL-32, andIL-32 may play an important role in inflammatory responses and pancreatic cancer growth.
Epithelial overexpression of interleukin‐32α in inflammatory bowel disease
- Medicine, Biology
- 2007
Epithelial IL‐32α expression was increased in IBD patients, and in CD patients in particular, and might be involved in the pathophysiology of IBD as a proinflammatory cytokine and a mediator of innate immune response.
The role of IL-32 in cutaneous T-cell lymphoma.
- Biology, MedicineThe Journal of investigative dermatology
- 2014
The results suggest that IL-32 has a role in the formation and maintenance of CTCL lesions, providing a possible therapeutic target for patients with this disease.