Interleukin-3 signals through multiple isoforms of Stat5.

  title={Interleukin-3 signals through multiple isoforms of Stat5.},
  author={M Azam and Hediye Erdjument-Bromage and Brent L. Kreider and Mingjing Xia and Frederick W. Quelle and Rajatava Basu and Chris J.M Saris and Paul Tempst and James N. Ihle and C. Barbara Schindler},
  journal={The EMBO journal},
  volume={14 7},
The interleukin (IL)-3 family of cytokines mediates its numerous effects on myeloid growth and maturation by binding a family of related receptors. It has been shown recently that IL-3 induces the activation of two distinct cytoplasmic signal transducing factors (STFs) that are likely to mediate the induction of immediate early genes. In immature myeloid cells, IL-3 activates STF-IL-3a, which comprises two tyrosine-phosphorylated DNA binding proteins of 77 and 80 kDa. In mature myeloid cells… CONTINUE READING