Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents

@article{Collins1992Interleukin3P,
  title={Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents},
  author={Mary Kathryn Collins and Jacqueline Marvel and Prupti Malde and Abelardo L{\'o}pez-Rivas},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={1043 - 1051}
}
Murine bone marrow-derived cells, dependent on interleukin 3 (IL-3) for their growth in culture, undergo programmed cell, or apoptosis, upon cytokine withdrawal. Here it is reported that a variety of DNA damaging agents cause a more rapid onset of apoptosis in a factor-dependent cell line, BAF3, deprived of IL-3. In contrast, when cultured in the presence of IL-3, or other growth promoting factors, BAF3 cells are highly resistant to X-irradiation and the cytotoxic drugs etoposide and cisplatin… CONTINUE READING

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