Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region.

  title={Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region.},
  author={Wen-yan He and Yu Lan and Hui-yu Yao and Zhuan Li and Xiao-yan Wang and Xiu-Sen Li and Jiyan Zhang and Yu Zhang and Bing Liu and Ning Mao},
  volume={95 6},
BACKGROUND The hemangioblast is a bi-potential precursor cell with the capacity to differentiate into hematopoietic and vascular cells. In mouse E7.0-7.5 embryos, the hemangioblast can be identified by a clonal blast colony-forming cell (BL-CFC) assay or single cell OP9 co-culture. However, the ontogeny of the hemangioblast in mid-gestation embryos is poorly defined. DESIGN AND METHODS The BL-CFC assay and the OP9 system were combined to illustrate the hemangioblast with lymphomyeloid and… CONTINUE READING


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