Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

@article{Weber2015Interleukin3AA,
  title={Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis},
  author={Georg F Weber and Benjamin G. Chousterman and Shun He and Ashley M. Fenn and Manfred Nairz and Atsushi Anzai and Thorsten Brenner and Florian Uhle and Yoshiko Iwamoto and Clinton S. Robbins and Lorette Noiret and Sarah L. Maier and Tina Z{\"o}nnchen and Nuh N. Rahbari and Sebastian Sch{\"o}lch and Anne Klotzsche-von Ameln and Triantafyllos Chavakis and Juergen Weitz and Stefan Hofer and Markus A. Weigand Weigand and Matthias Nahrendorf and Ralph Weissleder and Filip K Swirski},
  journal={Science},
  year={2015},
  volume={347},
  pages={1260-1265}
}
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6Chigh monocytes and neutrophils and fuels a… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 20 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 67 CITATIONS, ESTIMATED 48% COVERAGE

143 Citations

0204020152016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 143 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…