Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3.

@article{Nagata1996Interleukin3A,
  title={Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3.},
  author={Yuka Nagata and Kazuo Todokoro},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={221 3},
  pages={785-9}
}
It has been described that interleukin 3 (IL3) activates JAK2, which in turn stimulates STAT5 activation. We found, however, that IL3 induces tyrosine-phosphorylation of Tyk2 as well as JAK2 in IL3-dependent mouse cell lines, FDC-P2 and Ba/F3. Furthermore, we found that IL3 induces activation of not only STAT5 but also STAT1 and STAT3. Taken together with other observations, these results indicate that IL3, erythropoietin and thrombopoietin share a common JAK-STAT signaling pathway. 

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