Interleukin-3. Biologic effects and clinical impact.


Human interleukin-3 (IL-3) is expressed in yeast and has a specific activity of 5 x 10(7) U/mg of protein. It exerts functional and proliferative effects on multiple hematopoietic cell lineages including the neutrophil, eosinophil, basophil, monocytic, and thrombopoietic cell lines. IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) share common binding capacities on hematopoietic cells. Each of these agents has entered clinical trials. The clinical experiences with IL-3 alone and in combination with GM-CSF in a Phase I/II trial are summarized in this report.


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@article{Oster1991Interleukin3BE, title={Interleukin-3. Biologic effects and clinical impact.}, author={W . Oster and J Frisch and Uwe Nicolay and Guido Schulz}, journal={Cancer}, year={1991}, volume={67 10 Suppl}, pages={2712-7} }