Interleukin-28A triggers wound healing migration of bladder cancer cells via NF-κB-mediated MMP-9 expression inducing the MAPK pathway.

@article{Lee2012Interleukin28ATW,
  title={Interleukin-28A triggers wound healing migration of bladder cancer cells via NF-κB-mediated MMP-9 expression inducing the MAPK pathway.},
  author={Se-Jung Lee and Jung-Hyurk Lim and Young Hyun Choi and W. -G. Kim and Sung-Kwon Moon},
  journal={Cellular signalling},
  year={2012},
  volume={24 9},
  pages={1734-42}
}
Interleukin (IL)-28A, also called IFN-λ2, is a member of the classIIcytokine family and has demonstrated anti-proliferative and anti-viral signals. The present study demonstrated migration inducement of IL-28A-treated bladder cancer cells - a novel function. RNA microarray analysis showed an enhanced expression of IL-28A and its receptor IL-28AR1 in muscle invasive urothelial carcinoma in a human bladder. Strong expression of IL-28A and IL-28AR1 was detected in bladder cancer tissues and cell… CONTINUE READING

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