Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment.

@article{Wang2008Interleukin27SE,
  title={Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment.},
  author={Jinghua Wang and Guangyou Wang and Bo Sun and Hulun Li and Lili Mu and Qi Wang and Guozhong Li and Lijun Shi and Lianhong Jin and Nikolaos Kostulas},
  journal={Journal of autoimmunity},
  year={2008},
  volume={30 4},
  pages={222-9}
}
Interleukin (IL)-17 is a key inflammatory cytokine in autoimmune disease and may play an important role in the development of experimental autoimmune encephalomyelitis (EAE). In this study, we observed decreased IL-17 and increased IL-27 in EAE rats treated with bone marrow stromal cells (BMSCs). Neutralization of IL-27 resulted in recovery of the BMSCs… CONTINUE READING