Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

@article{Stumhofer2006Interleukin2N,
  title={Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system},
  author={Jason S. Stumhofer and Arian D J Laurence and Emma H Wilson and Elaine Shinwei Huang and Cristina M. Tato and Leanne M. Johnson and Alejandro V Villarino and Qiulong Huang and Akihiko Yoshimura and David W Sehy and Christiaan J. M. Saris and John J O'Shea and Lothar Hennighausen and Matthias Ernst and Christopher A Hunter},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={937-945}
}
Studies have focused on the events that influence the development of interleukin 17 (IL-17)–producing T helper cells (TH-17 cells) associated with autoimmunity, such as experimental autoimmune encephalitis, but relatively little is known about the cytokines that antagonize TH-17 cell effector responses. Here we show that IL-27 receptor–deficient mice… CONTINUE READING