Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma.

Abstract

PURPOSE Multiple myeloma (MM) derives from plasmablast/plasma cells that accumulate in the bone marrow. Different microenvironmental factors may promote metastatic dissemination especially to the skeleton, causing bone destruction. The balance between osteoclast and osteoblast activity represents a critical issue in bone remodeling. Thus, we investigated… (More)
DOI: 10.1158/1078-0432.CCR-10-0173

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