Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors

  title={Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors},
  author={Karlo D. T. Natividad and Simon Junankar and Norhanani Mohd Redzwan and Radhika Nair and Rushika C. Wirasinha and C Christopher King and Robert Brink and Alexander Swarbrick and Marcel L Batten},
  booktitle={PloS one},
Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor… CONTINUE READING
7 Citations
51 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…