Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors

@inproceedings{Natividad2013Interleukin27SP,
  title={Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors},
  author={Karlo D. T. Natividad and Simon Junankar and Norhanani Mohd Redzwan and Radhika Nair and Rushika C. Wirasinha and C Christopher King and Robert Brink and Alexander Swarbrick and Marcel L Batten},
  booktitle={PloS one},
  year={2013}
}
Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor… CONTINUE READING
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