Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA.

@article{Fan2012Interleukin25PB,
  title={Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA.},
  author={Yu Fan and Ze Lv and Xiujuan Yao and Weihu Wang and Kewu Huang and Qiu Meng and Cailong Fang and Tak Hong Lee and Christopher J. Corrigan and Yong Q An and Sun Ying},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2012},
  volume={42 11},
  pages={1604-14}
}
BACKGROUND Unlike other IL-17 family members, the Th2-derived cytokine IL-25 (IL-17E) induces (promotes) Th2 responses. One or both of the two receptors for IL-25 (IL-17RA, IL-17RB) is expressed on inflammatory cells and tissue structural cells, suggesting that in addition to promoting Th2-type inflammation IL-25 may also act on structural cells at sites of Th2-type inflammation such as in the asthmatic bronchial mucosa to promote remodelling changes. OBJECTIVE Our previous studies showed… CONTINUE READING
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