Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.

@article{Wong2005Interleukin25inducedCA,
  title={Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.},
  author={Chun Kwok Wong and Phyllis F Y Cheung and W. K. Ip and Christopher W K Lam},
  journal={American journal of respiratory cell and molecular biology},
  year={2005},
  volume={33 2},
  pages={186-94}
}
Interleukin (IL)-25, a novel Th2 cytokine, is capable of amplifying allergic inflammation. We investigated the modulation of nuclear factor (NF)-kappaB and mitogen-activated protein kinases (MAPK) pathways in IL-25-activated eosinophils, the principal effector cells of allergic inflammation, for the in vitro release of chemokines including monocyte chemoattractant protein-1 (MCP-1), IL-8, and macrophage inflammatory protein (MIP)-1alpha, and inflammatory cytokine IL-6. Gene expression of… CONTINUE READING

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Clinical applications of cytokine assays

  • CK Wong, Lam CWK
  • Adv Clin Chem
  • 2003
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