Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.

@article{Zheng2008Interleukin24OT,
  title={Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.},
  author={Mingzhong Zheng and Dora Bocangel and Rajagopal Ramesh and Suhendan Ekmekcioglu and Nancy J. Poindexter and Elizabeth Ann Grimm and Sunil Chada},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 12},
  pages={3842-51}
}
Melanoma is the most malignant of skin cancers, highly resistant to chemotherapy and radiotherapy. Temozolomide, a promising new derivative of dacarbazine, is currently being tested for treatment of metastatic melanoma. Resistance to alkylating agents such as temozolomide correlates with increased expression of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). Interleukin-24 (IL-24; mda-7) is a tumor suppressor cytokine that selectively inhibits tumor cell growth by inducing… CONTINUE READING
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