Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease.

@article{Das2009Interleukin23SB,
  title={Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease.},
  author={Rupali Das and Xiao Chen and Richard A. Komorowski and Martin J. Hessner and William R. Drobyski},
  journal={Blood},
  year={2009},
  volume={113 10},
  pages={
          2352-62
        }
}

• Rupali Das, Xiao Chen, +2 authors William R. Drobyski
• Published in Blood 2009
• DOI:10.1182/blood-2008-08-175448

Damage to the gastrointestinal tract during graft-versus-host disease (GVHD) from the conditioning regimen in conjunction with alloreactive donor T cells plays a pivotal role in the pathogenesis of this disease. In this study, we have identified secretion of interleukin-23 (IL-23) by donor antigen-presenting cells (APCs) as a critical event in the induction of GVHD of the colon linking conditioning regimen-induced mucosal injury and lipopolysaccharide (LPS) translocation to subsequent… CONTINUE READING

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