Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17*

@article{Aggarwal2003Interleukin23PA,
  title={Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17*},
  author={Sudeepta Aggarwal and Nico Ghilardi and Ming Hong Xie and Frederic J. de Sauvage and Austin L. Belmont Gurney},
  journal={The Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={1910 - 1914}
}
Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated… 

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