Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.

  title={Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.},
  author={Renu Jain and Yi Chen and Yuka Kanno and Barbara Joyce-Shaikh and Golnaz Vahedi and Kiyoshi Hirahara and Wendy M. Blumenschein and Selvakumar Sukumar and Christopher J Haines and Svetlana Sadekova and Terrill Mcclanahan and Mandy J McGeachy and John J O'Shea and Daniel J. Cua},
  volume={44 1},
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory function of Th17 cells. In contrast to thymic deletion of Blimp-1, which causes T cell development defects and spontaneous autoimmunity, peripheral deletion of this transcription factor resulted in reduced… CONTINUE READING
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Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling

  • K. Ghoreschi, A. Laurence, +8 authors N Bouladoux
  • Nature 467,
  • 2010
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