Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells

@inproceedings{Liu2017Interleukin22PA,
  title={Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells},
  author={Yulin Liu and Fan Xiang and Yongming Huang and Liang Shi and Chaojie Hu and Yiming Yang and Di Wang and Nan He and Kaixiong Tao and Ke Wu and Guobin Wang},
  booktitle={Oncotarget},
  year={2017}
}
Interleukin-22 has been explored extensively in human cancer, but its functions and underlying mechanisms are incompletely understood. Here, we show that aberrant interleukin-22 expression facilitates aerobic glycolysis in colon cancer cells. Elevated interleukin-22 mRNA expression was observed and positively correlated with hexokinase-2 in colon cancer tissues. In vitro, interleukin-22 enhanced glucose consumption and lactate production via targeting hexokinase-2 in colon cancer cells… CONTINUE READING