Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression.

@article{Dhiman2014Interleukin2I,
  title={Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression.},
  author={Rohan Dhiman and Sambasivan Venkatasubramanian and Padmaja Paidipally and Peter F. Barnes and Amy R. Tvinnereim and Ramakrishna Vankayalapati},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={209 4},
  pages={578-87}
}
Previously, we found that interleukin 22 (IL-22) inhibits intracellular growth of Mycobacterium tuberculosis in human monocyte-derived macrophages (MDMs). In the current study, we determined the mechanisms underlying these effects. We found that W7, a phagolysosomal fusion inhibitor, abrogates IL-22-dependent M. tuberculosis growth inhibition in MDMs, suggesting that IL-22 acts through enhanced phagolysosomal fusion. Our microarray analysis indicated that recombinant IL-22 (rIL-22) enhances the… CONTINUE READING

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