Interleukin 22 early affects keratinocyte differentiation, but not proliferation, in a three-dimensional model of normal human skin.

@article{Donetti2016Interleukin2E,
  title={Interleukin 22 early affects keratinocyte differentiation, but not proliferation, in a three-dimensional model of normal human skin.},
  author={Elena Donetti and Laura Cornaghi and Francesca Arnaboldi and Federica Landoni and Paolo Romagnoli and Nicolino Mastroianni and Leonardo Pescitelli and Franz Wilhelm Baruffaldi Preis and F Prignano},
  journal={Experimental cell research},
  year={2016},
  volume={345 2},
  pages={247-54}
}
Interleukin (IL)-22 is a pro-inflammatory cytokine driving the progression of the psoriatic lesion with other cytokines, as Tumor Necrosis Factor (TNF)-alpha and IL-17. Our study was aimed at evaluating the early effect of IL-22 alone or in combination with TNF-alpha and IL-17 by immunofluorescence on i) keratinocyte (KC) proliferation, ii) terminal differentiation biomarkers as keratin (K) 10 and 17 expression, iii) intercellular junctions. Transmission electron microscopy (TEM) analysis was… CONTINUE READING