Interleukin-22 aggravates murine acute graft-versus-host disease by expanding effector T cell and reducing regulatory T cell.

@article{Zhao2014Interleukin22AM,
  title={Interleukin-22 aggravates murine acute graft-versus-host disease by expanding effector T cell and reducing regulatory T cell.},
  author={Kai Zhao and Dongmei Zhao and Dong Ling Huang and Lingling Yin and Chong Xi Chen and Bin Pan and Qingyun Wu and Zhenyu Li and Yao Yao and Erxia Shen and Ling-yu Zeng and Kailin Xu},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2014},
  volume={34 9},
  pages={707-15}
}
Graft-versus-host disease (GVHD) as a major complication after allogeneic hematopoietic stem cell transplantation is not well prevented now. We have observed that interleukin-22 (IL-22) produced by Th22, Th1, and Th17 cells participated in GVHD development in our previous study. However, the role of IL-22 in GVHD is still ambiguous. The aim of this study was to illuminate the pathological or protective function and the potential mechanism of IL-22 in the GVHD process. In the present study, we… CONTINUE READING
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