Interleukin-22: a potential immunomodulatory molecule in the lung.

  title={Interleukin-22: a potential immunomodulatory molecule in the lung.},
  author={Hayley A. Whittington and Lynne V Armstrong and Kay M. Uppington and Ann B. Millar},
  journal={American journal of respiratory cell and molecular biology},
  volume={31 2},
Interleukin (IL)-22 is a member of the human type I interferon family, which includes IL-10. IL-22 has the potential to interact with IL-10 because it binds to the IL-10R2c chain with IL-22R1 in its receptor complex. Binding can be blocked by the soluble receptor, IL-22 binding protein (IL-22BP). We hypothesize that IL-22 and IL-22BP are involved in inflammatory regulation and its subsequent role in the pathogenesis of inflammatory lung disease. We have demonstrated IL-22 mRNA expression in… CONTINUE READING


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