Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells

Abstract

IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T cells or curtailed expansion of natural Treg remains unclear… (More)
DOI: 10.1007/s00262-017-1970-6

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