Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.

@article{Lindner2013Interleukin2G,
  title={Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.},
  author={Stefanie Lindner and Karen Dahlke and Kai Sontheimer and Magdalena Hagn and Christof T Kaltenmeier and Thomas F E Barth and Thamara Beyer and Frank Reister and Dorit Fabricius and Ramin Lotfi and Oleg Lunov and Gerd Ulrich Nienhaus and Thomas Simmet and Rolf Kreienberg and Peter Moeller and Hubert Schrezenmeier and Bernd Jahrsdoerfer},
  journal={Cancer research},
  year={2013},
  volume={73 8},
  pages={
          2468-79
        }
}
  • Stefanie Lindner, Karen Dahlke, +14 authors Bernd Jahrsdoerfer
  • Published in Cancer research 2013
  • Medicine
  • The pathogenic impact of tumor-infiltrating B cells is unresolved at present, however, some studies suggest that they may have immune regulatory potential. Here, we report that the microenvironment of various solid tumors includes B cells that express granzyme B (GrB, GZMB), where these B cells can be found adjacent to interleukin (IL)-21-secreting regulatory T cells (Treg) that contribute to immune tolerance of tumor antigens. Because Tregs and plasmacytoid dendritic cells are known to… CONTINUE READING

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