Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.

@article{Lindner2013Interleukin2G,
  title={Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.},
  author={S. Lindner and Karen Dahlke and Kai Sontheimer and M. Hagn and C. Kaltenmeier and T. Barth and Thamara Beyer and F. Reister and D. Fabricius and R. Lotfi and O. Lunov and G. Nienhaus and T. Simmet and R. Kreienberg and P. Möller and H. Schrezenmeier and B. Jahrsd{\"o}rfer},
  journal={Cancer research},
  year={2013},
  volume={73 8},
  pages={
          2468-79
        }
}
The pathogenic impact of tumor-infiltrating B cells is unresolved at present, however, some studies suggest that they may have immune regulatory potential. Here, we report that the microenvironment of various solid tumors includes B cells that express granzyme B (GrB, GZMB), where these B cells can be found adjacent to interleukin (IL)-21-secreting regulatory T cells (Treg) that contribute to immune tolerance of tumor antigens. Because Tregs and plasmacytoid dendritic cells are known to… Expand
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