Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease.

@article{Monteleone2005Interleukin21ET,
  title={Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease.},
  author={Giovanni Monteleone and Ivan Monteleone and Daniele Fina and Piero Vavassori and Giovanna Del Vecchio Blanco and Roberta Caruso and Roberto Tersigni and Luciano Alessandroni and Livia Biancone and Gian Carlo Naccari and Thomas Macdonald and Francesco Pallone},
  journal={Gastroenterology},
  year={2005},
  volume={128 3},
  pages={687-94}
}
BACKGROUND & AIMS T-helper (Th)1 cells play a central role in the pathogenesis of tissue damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell commitment in CD, but other cytokines are needed to maintain activated Th1 cells in the mucosa. In this study, we examined the expression and role of IL-21, a T-cell-derived cytokine of the IL-2 family; in tissues and cells isolated from patients with inflammatory bowel disease. METHODS IL-21 was examined by Western… CONTINUE READING