Interleukin 21 as a target of intervention in autoimmune disease.

@article{Ettinger2008Interleukin2A,
  title={Interleukin 21 as a target of intervention in autoimmune disease.},
  author={Rachel Ettinger and Stefan Kuchen and Peter E Lipsky},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 Suppl 3},
  pages={iii83-6}
}
Interleukin 21 (IL21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). The IL21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. One essential role of IL21 is the promotion of B-cell activation and differentiation or death during humoral immune responses… CONTINUE READING

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