Interleukin 21 as a target of intervention in autoimmune disease.

  title={Interleukin 21 as a target of intervention in autoimmune disease.},
  author={Rachel Ettinger and Stefan Kuchen and Peter E Lipsky},
  journal={Annals of the rheumatic diseases},
  volume={67 Suppl 3},
Interleukin 21 (IL21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). The IL21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. One essential role of IL21 is the promotion of B-cell activation and differentiation or death during humoral immune responses… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 31 extracted citations

Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity

Clinical reviews in allergy & immunology • 2017
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…