Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells

@inproceedings{McMichael2015Interleukin21AN,
  title={Interleukin-21 activates natural killer cell activity against cetuximab-coated pancreatic tumor cells},
  author={Elizabeth L McMichael and Alena Cristin Jaime-Ramirez and Kristan D Guenterberg and Eric A. Luedke and Lakhvir S. Atwal and William E. Carson},
  year={2015}
}
Natural killer (NK) cells are large granular lymphocytes that play a critical role in anti-cancer mechanisms. These effector cells mediate antibody-dependent cellular cytotoxicity (ADCC) and produce IFN-g in response to antibody-coated targets. The monoclonal antibody cetuximab targets the epidermal growth factor receptor (EGFR), which is over expressed in the majority of pancreatic cancers, but fails to effectively block MAP kinase activity when KRAS is concurrently mutated. Interleukin-21 (IL… CONTINUE READING
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