Interleukin-21: a double-edged sword with therapeutic potential

  title={Interleukin-21: a double-edged sword with therapeutic potential},
  author={Rosanne Spolski and Warren J Leonard},
  journal={Nature Reviews Drug Discovery},
Interleukin-21 is a cytokine with broad pleiotropic actions that affect the differentiation and function of lymphoid and myeloid cells. Since its discovery in 2000, a tremendous amount has been learned about its biological actions and the molecular mechanisms controlling IL-21-mediated cellular responses. IL-21 regulates both innate and adaptive immune responses, and it not only has key roles in antitumour and antiviral responses but also exerts major effects on inflammatory responses that… CONTINUE READING