Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity.

@article{Rizzo1994Interleukin2TP,
  title={Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity.},
  author={Luiz Vicente Rizzo and Nancy E. Miller-Rivero and Chi Chao Chan and Barbara N Wiggert and Robert B. Nussenblatt and Rachel R Caspi},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 4},
  pages={1668-72}
}
The present study addresses the feasibility of potentiating oral tolerance by immunomanipulation, using the murine model of experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP). Three feedings of 0.2 mg IRBP every other day before immunization did not protect against EAU, whereas a similar regimen of five doses was protective. However, supplementing the nonprotective 3x regimen with as little as one… CONTINUE READING

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