Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells.

@article{Waters1990Interleukin2R,
  title={Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells.},
  author={C. A. Waters and P A Schimke and Catherine E. Snider and K. Shinzawa Itoh and Kent A. Smith and Jean C. Nichols and Terry B. Strom and John A Murphy},
  journal={European journal of immunology},
  year={1990},
  volume={20 4},
  pages={
          785-91
        }
}
The receptor binding requirements for entry of the NAD+ ADP-ribosyltransferase component of DAB486-IL 2 into target cells were examined. Experiments utilizing cell lines bearing either high-affinity or individual subunits of the interleukin 2 receptor (IL 2R) as well as human peripheral blood mononuclear cells with natural killer activity demonstrate that the high-affinity receptor facilitates delivery of fragment A from DAB486-IL 2 to the cytosol approximately 1000 times more efficiently than… CONTINUE READING
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