Interleukin-2 receptor signaling: at the interface between tolerance and immunity.


Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo. IL-2R signaling influences two discrete aspects of immune responses by CD8(+) T cells, terminal differentiation of… (More)
DOI: 10.1016/j.immuni.2010.08.004


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