Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes.

  title={Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes.},
  author={Antonio de la Hera and Mar{\'i}a L Toribio and Carlos Renteria Marquez and Carlos Martinez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 18},
Human thymocytes bearing T3 but neither T4 nor T8 antigens (T3+4-8- cells) were obtained after negative selection of thymocytes, either fresh or cultured in medium containing recombinant interleukin 2 (IL-2), by treatment with Na1/34, OKT4A and B9.4 monoclonal antibodies (which recognize T6, T4, and T8 antigens, respectively) and complement. Quantitative flow cytometry showed a 98% pure population of T3+4-8- lymphocytes, which included proliferating cells. The growth and maturation requirements… CONTINUE READING



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