Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.

@article{Turner1991Interleukin2I,
  title={Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.},
  author={Bruce C. Turner and U Rapp and Harald App and Maiya Greene and Kunio Dobashi and Jennifer Reed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 4},
  pages={1227-31}
}
Interleukin 2 (IL-2) is a lymphokine, produced by T cells upon antigenic or mitogenic stimulation, that is a critical regulator of T-cell proliferation. Although the binding of IL-2 to its receptor has been well characterized, the molecular mechanisms by which IL-2 transmits its signal from the membrane to the interior of the cell are poorly understood. Like most other growth factors, IL-2 causes rapid phosphorylation of proteins within its target cells. Unlike many other growth factors… CONTINUE READING

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