Interleukin 2-induced expression of proliferating cell nuclear antigen is regulated by transcriptional and post-transcriptional mechanisms.

@article{ShipmanAppasamy1990Interleukin2E,
  title={Interleukin 2-induced expression of proliferating cell nuclear antigen is regulated by transcriptional and post-transcriptional mechanisms.},
  author={P M Shipman-Appasamy and Kenneth S. Cohen and Michael B. Prystowsky},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 31},
  pages={19180-4}
}
Proliferating cell nuclear antigen (PCNA) is an auxiliary protein required for leading strand DNA synthesis by polymerase delta. Steady-state levels of PCNA RNA increase during interleukin 2 stimulated G1 activation of cloned T cells (L2 cells) and correlate with expression of the PCNA protein. We demonstrate that the initial (G1) rapid rise in PCNA RNA levels is predominantly related to increased transcription. The slower rate of increase in PCNA RNA at the initial G1-S transition is related… CONTINUE READING

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