Interleukin-2-induced cytotoxicity of Chediak-Higashi lymphocytes.

@article{Holcombe1992Interleukin2inducedCO,
  title={Interleukin-2-induced cytotoxicity of Chediak-Higashi lymphocytes.},
  author={Randall F. Holcombe},
  journal={Acta haematologica},
  year={1992},
  volume={87 1-2},
  pages={
          45-8
        }
}
Peripheral blood mononuclear cells (PBMCs) from patients with Chediak-Higashi syndrome (CHS) exhibit minimal natural-killer-like cytotoxicity by standard 51Cr-release assays in vitro. However, a CHS-derived gamma delta-T-cell clone maintained in long-term culture with low-dose interleukin-2 (IL-2) does exhibit cytotoxic activity. PBMCs from 2 patients with CHS were stimulated with low-dose IL-2 in short-term culture and compared with a control for induction of cytotoxicity against a panel of… CONTINUE READING
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